The existential dimension, some times referred to as the religious or spiritual dimension, is essential for health and health-related qualityof life (HQoL). Research has established a significant link between the existential health dimension and various conditions and diagnoses. The lack of an established definition of the existential dimension constitutes a challenge. Therefore, the starting point in this article is operationalisation. The World Health Organization(WHO) developed transcultural survey for measuring health-related quality of life, including a model for spiritual,religious,and personal beliefs (WHOQOL-SRPB). This article first presents existential aspects relevant to HQoL and then a model for systematic existential health interventions with the SRPB aspects. Finally, it presents the Social Determinants of Health (SDH) model with the addition of the existential health dimension.